amyloid-beta peptide 40/42 in plasma
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Indications
- investigative use to identify elderly with preclinical Alzheimer's disease & for monitoring response to therapy[4]
Clinical significance
- higher plasma Abeta40/42 is associated with
- more pronounced cognitive decline over time[2]*
- higher risk of cardiovascular disease, mortality from heart failure, & kidney disease[5]
* authors suggest plasma Abeta40/42 may be used to identify people at risk of cognitive decline [2.3]
* it is difficult to reconcile this with comments in ref[1]
Methods
- mass spectrometry-based methods showed better discriminative accuracy than immunoassays[1]
More general terms
Additional terms
Components
References
- ↑ 1.0 1.1 1.2 Nakamura A, Kaneko N, Villemagne VL et al High performance plasma amyloid-beta biomarkers for Alzheimer's disease. Nature. 2018 Feb 8;554(7691):249-254 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29420472 https://www.nature.com/articles/nature25456
- ↑ 2.0 2.1 Giudici KV, de Souto Barreto P, Guyonnet S et al Assessment of Plasma Amyloid-beta42/40 and Cognitive Decline Among Community-Dwelling Older Adults. JAMA Netw Open. 2020;3(12):e2028634 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33331917 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774284
- ↑ Pereira JB et al. Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects. Brain 2021 Jun 2; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34077494 https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab163/6291241
- ↑ 4.0 4.1 Janelidze S, Teunissen CE, Zetterberg H et al Head-to-Head Comparison of 8 Plasma Amyloid-beta 42/40 Assays in Alzheimer Disease. JAMA Neurol. Published online September 20, 2021. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34542571 https://jamanetwork.com/journals/jamaneurology/fullarticle/2784411
- ↑ 5.0 5.1 Dark HE, Paterson C, Daya GN et al Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk. Ann Neurol. 2023. Oct 6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37801487 https://onlinelibrary.wiley.com/doi/full/10.1002/ana.26817