MAP/microtubule affinity-regulating kinase 3; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; protein kinase STK10; Ser/Thr protein kinase PAR-1; par-1a; serine/threonine protein kinase p78 (MARK3, CTAK1, EMK2)

Function

• role in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 & MAP4.
• phosphorylates CDC25C on Ser-216 regulates localization & activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 & 14-3-3 & export from the nucleus
• activated by phosphorylation on Thr-211
• inhibited by phosphorylation on Thr-564
• phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39
• phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 KA1 (kinase-associated) domain
• contains 1 protein kinase domain
• contains 1 UBA domain

Compartment

cell membrane; peripheral membrane protein

Alternative splicing

named isoforms=6

Expression

ubiquitous

More general terms

• MAP/microtubule affinity-regulating kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4140
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4140
• OMIM: https://mirror.omim.org/entry/602678
• UniProt: http://www.uniprot.org/uniprot/P27448.html