microtubule-associated protein 2; MAP-2 (MAP2)

Function

• exact function of MAP2 is unknown
• may stabilize microtubules against depolymerization
• may have a stiffening effect on microtubules
• MAP2A is phosphorylated
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 3 Tau/MAP repeats

Compartment

cytoplasm, cytoskeleton (probable)

Alternative splicing

named isoforms=3; MAP2A, MAP2B, MAP2C Additional isoforms seem to exist

Expression

neurons

Notes

• some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• microtubule-associated protein (MAP)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P11137.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4133
• OMIM: https://mirror.omim.org/entry/157130