tight junction protein ZO-2; Zonula occludens protein 2; Zona occludens protein 2; tight junction protein 2 (TJP2, X104, ZO2)
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Function
- plays a role in tight junctions & adherens junctions
- homodimer & heterodimer with ZO1
- interacts with occludin, SAFB & UBN1
- interaction with SAFB occurs in the nucleus
- interacts with SCRIB
Structure
- belongs to the MAGUK family
- contains 1 guanylate kinase-like domain
- contains 3 PDZ domain (DHR domain)s
- contains 1 SH3 domain
Compartment
- cell junction, adherens junction
- cell membrane; peripheral membrane protein; cytoplasmic side
- cell junction, tight junction (putative)
- nucleus (putative)
- nuclear under environmental stress conditions & in migratory endothelial cells & subconfluent epithelial cell cultures
Alternative splicing
named isoforms=5 Alternative promoter: yes
Expression
- found in epithelial cell junctions
- isoform A1 is abundant in the heart & brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart & placenta
- in brain & skeletal muscle, only isoform A1 is detectable.
- isoform C1 is found in normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in normal tissue
Pathology
- defects in TJP2 are involved in familial hypercholanemia