G-protein-signaling modulator 2 (mosaic protein LGN, GPSM2, LGN)
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Function
- role in spindle pole orientation
- interacts & contributes to functional activity of Gi alpha proteins
- acts to stabilize apical complex during neuroblast divisions
- interacts with LLGL2
- interacts with INSC/inscuteable & probably with F2RL2
Structure
- belongs to the GPSM family
- contains 4 GoLoco domains
- contains 8 TPR repeats
Compartment
- cytoplasm, cell cortex
- localizes in cytoplasm during interphase & at cell periphery during metaphase
Expression
ubiquitously expressed
Pathology
- dysfunction of GPSM2 is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation & defect in cell division through mis-localization of mitotic splindle regulator protein NuMA