lethal(2) giant larvae protein homolog 2 (HGL, LLGL2)

Function

• component of GPSM2/PRKCI/PARD6B/LLGL2 complex
• phosphorylated at Ser-664 by PRKCI
• phosphorylation enhanced during cell polarization induced by Ca+2
• phosphorylation may occur during cell-cell contact-induced cell polarization & may contribute to segregation of LLGL2 from the GPSM2/PRKCI/PARD6B/LLGL2 complex
• overexpression of LLGL2 inhibits the tight junction formation

Structure

• belongs to the WD repeat L(2)GL family.
• contains 5 WD repeats

Alternative splicing

named isoforms=3

More general terms

• WD repeat protein family
• phosphoprotein

Component of

• GPSM2/PRKCI/PARD6B/LLGL2 complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q6P1M3.html