GPSM2/PRKCI/PARD6B/LLGL2 complex
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Function
- may ensure correct organization orientation of bipolar spindles for normal cell division
- role in the initial phase of establishment of epithelial cell polarity
Structure
Compartment
- cytoplasm
- localized in perinuclear structure & faintly at the cell-cell contacts sites during interphase
- localized at the cell periphery during metaphase
- cortical localization in mitotic cells
- found in the lateral region of polarized epithelial cells
Expression
- complex is enhanced during mitosis