coagulation factor XIII; fibrin-stabilizing factor

Function

• coagulation factor
• zymogen, activated by thrombin & Ca+2 to form factor XIIIa

Structure

• tetramer of two factor XIII A chains & two factor XIII B chains

Indications

• factor XIII deficiency

More general terms

• coagulation factor
• enzyme precursor (zymogen)
• multisubunit protein
• hematologic agent

Additional terms

• clot solubility in 5M urea
• coagulation cascade

Components

• coagulation factor XIII B subunit; protein-glutamine gamma-glutamyltransferase B chain; transglutaminase B chain; fibrin-stabilizing factor B subunit (F13B)
• coagulation factor XIII A subunit (protein-glutamine gamma-glutamyltransferase A chain, transglutaminase A chain, F13A1, F13A)