coagulation factor XIII A subunit (protein-glutamine gamma-glutamyltransferase A chain, transglutaminase A chain, F13A1, F13A)

Function

• A chain of coagulation factor XIII
• this is the activation peptide (factor XIIIA) released by thrombin

Cofactor: binds 1 Ca+2 per subunit

Structure

• belongs to the transglutaminase superfamily transglutaminase family

Compartment

• cytoplasm, secreted
• secreted into the blood plasma. cytoplasmic in most tissues, but also secreted in the blood plasma

Pathology

• defects in F13A1 are the cause of F13A deficiency

Polymorphism

• there are four main allelic forms of this protein F13A*1A, F13A*1B, F13A*2A & F13A*2B
• in addition two other intermediate forms (F13A*(2)A & F13A*(2)B) seem to exist

More general terms

• protein subunit
• Ca+2 binding protein

Component of

• coagulation factor XIII; fibrin-stabilizing factor

Database

• UniProt: http://www.uniprot.org/uniprot/P00488.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2162
• OMIM: https://mirror.omim.org/entry/134570