thrombomodulin; TM; fetomodulin; CD141 (THBD, THRM)

Function

• specific endothelial cell receptor
• forms a 1:1 stoichiometric complex with thrombin
• thrombin-thrombomodulin complex activates protein C
• activated protein C scissions the activated cofactors of the coagulation mechanism, factor Va & factor VIIIa, thus diminishes the amount of thrombin generated
• iron & 2-oxoglutarate dependent 3-hydroxylation of Asp & Asn is (R) stereospecific within EGF domains

Thrombomodulin stimulates:

• thrombin-mediated activatation of protein C
• antithrombin III inactivation of thrombin

Thrombomodulin inhibits:

• thrombin-mediated proteolysis of fibrinogen
• thrombin-mediated proteolysis of factor V
• thrombin activation of platelets

Structure

• N-glycosylated
• contains 1 C-type lectin domain
• contains 6 EGF-like domains

Compartment

membrane

Expression

• uniquely expressed by endothelial cells

Pathology

• defects in THBD are the cause of thrombophilia due to thrombomodulin defect

More general terms

• glycoprotein
• plasma membrane protein

More specific terms

• recombinant thrombomodulin

Database

• UniProt: http://www.uniprot.org/uniprot/P07204.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7056
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7056
• OMIM: https://mirror.omim.org/entry/188040