protein C, activated

Function

• vitamin K-dependent serine protease
• proteolytically inactivates coagulation factors: factor Va & factor VIIIa
• stimulates fibrinolysis
• activity is enhanced by protein S
• cleavage of factor Va by activated protein C occurs at amino acid residue 506, the site of factor V Leiden mutation

Expression

• plasma activity may be reduced as a result of acute thrombosis
• anticoagulation lowers activity of protein C in plasma.

Pathology

• see protein C deficiency

Pharmacology

• recombinant activated protein C, see drotrecogin alpha (Xigris)

More general terms

• coagulation factor
• serine protease trypsin family
• endogenous anticoagulant

More specific terms

• drotrecogin alpha (Xigris); recombinant protein C, activated

Additional terms

• coagulation cascade
• protein C deficiency
• protein C in plasma (protein C assay)
• protein C inhibitor; plasma serine protease inhibitor; acrosomal serine protease inhibitor; plasminogen activator inhibitor 3; PAI-3; PAI3; PCI; Serpin A5 (SERPINA5, PCI, PLANH3, PROCI)
• protein C; vitamin K-dependent protein C; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; contains: vitamin K-dependent protein C light chain; vitamin K-dependent protein C heavy chain; activation peptide (PROC)