protein C in plasma (protein C assay)
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Reference interval
- 70-140% of normal reference activity
- 2.82-5.65 ug/mL
Increases
- pharmaceutical agents:
- chemical interferences
- in vivo effects
Decreases
- pharmaceutical agents
- chemical interferences
- high factor VIII activity
- chemical interferences
- clinical disorders: hypercoagulability
- congenital deficiency
- acquired deficiency
- liver disease
- acute thrombosis[1]
- warfarin therapy
- protein-losing enteropathy[1]
Methods
- functional* clotting assay based on anticoagulant activity
- rocket immunoelectrophoresis
- enzyme-linked immunosorbant assays (ELISA)
* NOT useful if patient is anticoagulated
Specimen
- plasma (citrate)
- stable at room temperature for 8 hours
- stable at -20 degrees C for 1 month
More general terms
Additional terms
- activated protein C (APC) resistance assay
- protein C antigen in plasma
- protein C deficiency
- protein C; vitamin K-dependent protein C; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; contains: vitamin K-dependent protein C light chain; vitamin K-dependent protein C heavy chain; activation peptide (PROC)
References
- ↑ 1.0 1.1 1.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 17, 18. American College of Physicians, Philadelphia 1998, 2015, 2018
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ Protein C Functional Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030041.jsp
- ↑ Protein C Functional Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030113.jsp
- ↑ Panel of 4 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030177.jsp
- ↑ Mini Panel of 2 tests: Protein C Functional . Protein S Functional Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030182.jsp
- ↑ Protein C Functional Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp