Borrelia burgdorferi
Jump to navigation
Jump to search
Introduction
Etiologic agent of Lyme disease.
Epidemiology
4 stage life cycle generally completed in 2 years
Pathology
- a peptidoglycan in the cell envelope of Borrelia burgdorferi is released but not degraded when the bacterium dies[3]
- the peptidoglycan lingers in synovial fluid & elicits an ongoing immune response*
* systemic administration of the peptidoglycan ellicits acute arthritis in mice[3]
Laboratory
- Borrelia burgdorferi serology
- Borrelia burgdorferi antigen
- Borrelia burgdorferi DNA
- Borrelia burgdorferi culture
- see ARUP consult[2]
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ 2.0 2.1 ARUP Consult: Borrelia burgdorferi - Lyme Disease The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/borrelia-species
- ↑ 3.0 3.1 3.2 Jutras BL, Lochhead RB, Kloos ZA et al. Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proc Natl Acad Sci U S A 2019 Jul 2; 116:13498. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31209025 Free PMC Article https://www.pnas.org/content/116/27/13498