interleukin-1 receptor associated kinase 3; IL-1 receptor-associated kinase M (IRAK3, IRAK-M)

Function

• inhibits dissociation of IRAK1 & IRAK4 from Toll-like receptor signaling complex
• inhibits phosphorylation of IRAK1 & IRAK4
• low level autophosphorylation activity

Cofactor: Mg+2

Structure

• Ser-293 is present instead of the conserved Asp which is expected to be an active site residue
• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
• contains 1 death domain
• contains 1 protein kinase domain

Expression

expressed in peripheral blood lymphocytes

Pathology

• defects in IRAK3 are associated with susceptibility to asthma-related traits type 5

More general terms

• interleukin-1 receptor associated kinase (IRAK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11213
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11213
• OMIM: https://mirror.omim.org/entry/604459
• OMIM: https://mirror.omim.org/entry/611064
• UniProt: http://www.uniprot.org/uniprot/Q9Y616.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?