asthma-related traits
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Genetics
- polymorphisms in PTGDR are associated with susceptibility to asthma-related traits type 1
- defects in IRAK3 are associated with susceptibility to asthma-related traits type 5
- genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7
Clinical manifestations
- symptoms of asthma, such as coughing, wheezing & dyspnea
- atopic dermatitis
Laboratory
- serum IgE levels increased
Diagnostic procedures
- methacholine challenge test: bronchial hyperresponsiveness