chitinase-3-like protein 1; cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; 39 kD synovial protein; YKL-40 (CHI3L1)

Function

• carbohydrate-binding lectin with a preference for chitin
• may play a role in defense against pathogens, or in tissue remodeling
• may play an important role in the capacity of cells to respond to & cope with changes in their environment
• glycosylated

Structure

• monomer
• belongs to the glycosyl hydrolase 18 family

Compartment

secreted, extracellular space

Expression

• present in activated macrophages, articular chondrocytes, synovial cells as well as in liver
• undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts

Pathology

• genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7

More general terms

• glycoprotein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/P36222.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1116
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1116
• OMIM: https://mirror.omim.org/entry/601525
• OMIM: https://mirror.omim.org/entry/611960