prostaglandin D2 receptor DP1 (Prostanoid DP receptor, PGD receptor)

Function

• receptor for prostaglandin D2 (PGD2)
• activity mediated by Gs proteins that stimulate adenylate cyclase & increase intracellular cAMP
• mobilization of Ca+2 also occurs, but without formation of IP3
• neuroprotective for hippocampal pyramidal neurons in paradigms of glutamate toxicity; this contrasts with activation of CRTH2 (DP2) which promotes neuronal loss
• BW245C is agonist

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

expressed in retina & small intestine

Pathology

• genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• prostaglandin receptor

Additional terms

• G protein-coupled receptor GPR44; prostaglandin D2 receptor DP2; chemoattractant receptor-homologous molecule expressed on Th2 cells (PTGDR2, CRTH2, DP2)

Database

• OMIM: https://mirror.omim.org/entry/604687
• UniProt: http://www.uniprot.org/uniprot/Q13258.html