G protein-coupled receptor GPR44; prostaglandin D2 receptor DP2; chemoattractant receptor-homologous molecule expressed on Th2 cells (PTGDR2, CRTH2, DP2)

Function

• linked to Gi
• PGD2 produced by activated mast cells uses CRTH2 to induce intracellular Ca+2 mobilization & chemotaxis in Th2 cells (Gi-alpha-dependent)
• CRTH2 also mediates PGD2-dependent migration of blood eosinophils & basophils
• activation of CRTH2 (DP2) promoted neuronal loss in hippocampal pyramidal neurons in paradigms of glutamate toxicity; this contrasts with activation of PTGDR (DP1) which promotes neuronal survival

Structure

belongs to the G-protein coupled receptor 1 family

Expression

• expressed in thalamus, frontal cortex, pons, hippocampus hypothalamus (lower levels), caudate/putamen (lower levels) fetal liver, leukocytes, thymus
• selectively expressed in vivo in activated T-helper-2 (Th2) cells, including allergen-responsive Th2 cells, but not in B cells or NK cells

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• prostaglandin receptor

Additional terms

• prostaglandin D2 receptor DP1 (Prostanoid DP receptor, PGD receptor)

Database

• OMIM: https://mirror.omim.org/entry/604837
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Y4.html