mitogen-activated protein kinase kinase kinase 15 (MAP3K15)

Function

• component of a protein kinase signal transduction cascade
• activated by phosphorylation at Thr-812
• inhibited by phosphorylation at Ser-924 & Ser-994

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains an N-terminal autoinhibitory domain

Alternative splicing

named isoforms=3

More general terms

• MAP3K/MEKK

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=389840
• UniProt: http://www.uniprot.org/uniprot/Q6ZN16.html