mitogen-activated protein kinase kinase kinase 10 (MAP3K10, mixed lineage kinase [MLK] 2, MLK2, MST)

Function

• activates the JUN N-terminal pathway (putative)
• homodimerization via the leucine zipper domains is required for autophosphorylation & subsequent activation
• autophosphorylation on serine & threonine residues within the activation loop plays a role in enzyme activation

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2 (putative)

Structure

• homodimer (putative)
• belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain contains 1 SH3 domain

Expression

expressed in brain & skeletal muscle

More general terms

• MAP3K/MEKK
• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• UniProt: http://www.uniprot.org/uniprot/Q02779.html
• OMIM: https://mirror.omim.org/entry/600137
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4294