mitogen-activated protein kinase kinase kinase 12 (MAP3K12, leucine zipper protein kinase, ZPK, dual leucine zipper bearing kinase, DLK, MAPK-upstream kinase, MUK)

Function

• may be an activator of the JNK/SAPK pathway
• phosphorylates beta-casein, histone 1 & myelin basic protein in vitro
• interacts with MBIP
• autophosphorylated on Ser/Thr
• phosphorylated in cytosol under basal conditions & dephosphorylated when membrane-associated (putative)
• interacts with MBIP through the leucine-zipper motif

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm (putative)
• peripheral membrane (putative)

Expression

highly expressed in brain & kidney

More general terms

• MAP3K/MEKK

Database

• OMIM: https://mirror.omim.org/entry/600447
• UniProt: http://www.uniprot.org/uniprot/Q12852.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7786