mitogen-activated protein kinase kinase kinase 9 (MAP3K9, mixed lineage kinase [MLK] 1, MLK1, PRKE1)

Function

• activates the JUN N-terminal pathway
• homodimerization via the leucine zipper domains is required for autophosphorylation & subsequent activation
• autophosphorylation on Ser & Thr within the activation loop plays a role in enzyme activation
• Thr-312 is likely to be the main autophosphorylation site

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• homodimer (putative)
• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain contains 1 SH3 domain

Alternative splicing

named isoforms=2

Expression

• expressed in epithelial tumor cell lines of colonic, breast & esophageal origin

More general terms

• MAP3K/MEKK
• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• UniProt: http://www.uniprot.org/uniprot/P80192.html
• OMIM: https://mirror.omim.org/entry/600136
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4293