mitogen-activated protein kinase kinase kinase 6 (MAP3K6, apoptosis signal-regulating kinase 2, ASK-2, ASK2, MAPKKK6, MEKK6)

Function

• activates JNK pathways, not ERK or p38 pathways
• component of a protein kinase signal transduction cascade
• activates the JNK, but not ERK or p38 kinase pathways
• binds both upstream activators & downstream substrates in multimolecular complexes
• activated by phosphorylation on Thr-806
• catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability & the active configuration of MAP3K6 & MAP3K6 activating MAP3K5 by direct phosphorylation

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

More general terms

• MAP3K/MEKK

Database

• OMIM: https://mirror.omim.org/entry/604468
• UniProt: http://www.uniprot.org/uniprot/O95382.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9064