mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4 (MLK4, KIAA1804)

Function

• activates the JUN N-terminal pathway
• autophosphorylation on Ser & Thr within the activation loop plays a role in enzyme activation
• homodimerization via the leucine zipper domains required for autophosphorylation & subsequent activation

Cofactor: Mg+2 (putative)

Structure

• homodimer
• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=3

More general terms

• MAP3K/MEKK
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84451
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84451
• UniProt: http://www.uniprot.org/uniprot/Q5TCX8.html