mitogen-activated protein kinase kinase kinase 16 (MAP3K16, TAO1 kinase, serine/threonine protein kinase TAO1, thousand & one amino acid protein 1, STE20-like kinase PSK2, kinase from chicken homolog B, hKFC-B, TAOK1 KIAA1361)

Function

• phosphorylates MKK3 (putative)
• activates the p38 MAP kinase pathway through specific activation of upstream MKK3 kinase
• self-associates
• autophosphorylated (putative)

ATP + a protein = ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in testis > brain, placenta, colon & skeletal muscle

More general terms

• MAP3K/MEKK

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=600050
• UniProt: http://www.uniprot.org/uniprot/Q7L7X3.html