mitogen-activated protein kinase kinase kinase 8 (MAP3K8, cot proto-oncogene protein, cot kinase, Cot/Tpl-2, cancer Osaka thyroid oncogene protein, ESTF)

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Function

ATP + a protein <--> ADP + a phosphoprotein

Structure

Compartment

cytoplasm

Alternative initiation

Expression

  • expressed in several normal tissues & human tumor-derived cell lines
  • 58 kD form is activated specifically during the S & G2/M phases of the cell cycle

More general terms

References

  1. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
  2. Lin X, Cunningham ET Jr, Mu Y, Geleziunas R, Greene WC. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity. 1999 Feb;10(2):271-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10072079
  3. UniProt http://www.uniprot.org/uniprot/P41279.html

Database