lymphotoxin-beta; LT-beta; tumor necrosis factor C; TNF-C; tumor necrosis factor ligand superfamily member 3 (LTB, TNFC, TNFSF3)

Function

• cytokine
• binds to LTBR/TNFRSF3
• role in immune response regulation (putative)
• provides membrane anchor for attachment of the heterotrimeric complex to the cell surface
• isoform 2 is probably non-functional
• heterotrimer of either two LTB & one LTA subunits or (less prevalent) one LTB & two LTA subunits

Structure

belongs to the tumor necrosis factor family

Compartment

• membrane; single-pass type 2 membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

spleen & thymus

More general terms

• tumor necrosis factor (TNF) family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4050
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4050
• OMIM: https://mirror.omim.org/entry/600978
• UniProt: http://www.uniprot.org/uniprot/Q06643.html