C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; HM145; LD78 receptor; CD191 (CCR1, CMKBR1, CMKR1, SCYAR1)

Function

• receptor for a C-C type chemokine
• binds to MIP-1-alpha, MIP-1-delta, RANTES, & MCP-3 &, less efficiently, to MIP-1- beta or MCP-1
• upon ligand binding, transduces a signal by increasing intracellular Ca+2 level
• role in stem cell proliferation

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• widely expressed in different hematopoietic cells

More general terms

• CC chemokine receptor
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1230
• OMIM: https://mirror.omim.org/entry/601159
• UniProt: http://www.uniprot.org/uniprot/P32246.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1230