C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-alpha; small-inducible cytokine A3; tonsillar lymphocyte LD78 alpha protein; contains: MIP-1-alpha(4-69); LD78-alpha(4-69) (CCL3, G0S19-1, MIP1A, SCYA3)

Function

• monokine with inflammatory & chemokinetic properties
• binds to CCR1, CCR4 & CCR5
• one of the major HIV-suppressive factors produced by CD8+ T-cells
• recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV)
• N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells
• self-associates
• also heterodimer of MIP-1-alpha(4-69) & MIP-1-beta(3-69)

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• induced by phorbol esters TPA, PMA & phytohemagglutinin (T-cell mitogen)

More general terms

• monokine
• sis family protein
• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6348
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6348
• OMIM: https://mirror.omim.org/entry/182283
• UniProt: http://www.uniprot.org/uniprot/P10147.html