lens fiber major intrinsic protein; aquaporin-0; MIP26; MP26 (MIP, AQP0)

Function

• major component of lens fiber gap junctions
• water channel
• may be responsible for regulating osmolarity of the lens

Structure

• aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
• belongs to the MIP/aquaporin (TC 1.A.8) family

Compartment

• cell membrane
• cell junction, gap junction

Expression

major component of lens fiber gap junctions

Pathology

• defects in MIP are a cause of autosomal recessive congenital cataracts

More general terms

• transmembrane 6 protein
• aquaporin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4284
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4284
• OMIM: https://mirror.omim.org/entry/154050
• UniProt: http://www.uniprot.org/uniprot/P30301.html