C-C motif chemokine 3-like 1; G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; small-inducible cytokine A3-like 1; tonsillar lymphocyte LD78 beta protein; contains: LD78-beta(3-70); LD78-beta(5-70) (CCL3L1, D17S1718, G0S19-2, SCYA3L1, CCL3L3)

Function

• chemotactic for lymphocytes & monocytes
• ligand for CCR1, CCR3 & CCR5
• inhibitor of HIV-1-infection
• the N-terminal processed forms LD78-beta(3-70) & LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes
• cleavage to yield LD78- beta(3-70) is probably facilitated by DPP4
• the processed form LD78-beta(3-70)
  • shows a 20-30-fold higher chemotactic activity
  • is a very potent inhibitor of HIV1 infection
  • is also a ligand for CCR1, CCR3 & CCR5

Structure

belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Polymorphism

• the copy number of the CCL3L1 gene varies among individuals
• most individuals have 1-6 copies in the diploid genome
• rare individuals have zero or more than 6 copies

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=414062
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6349
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:414062
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6349
• OMIM: https://mirror.omim.org/entry/601395
• OMIM: https://mirror.omim.org/entry/609468
• UniProt: http://www.uniprot.org/uniprot/P16619.html