C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; protein H400; SIS-gamma; small-inducible cytokine A4; T-cell activation protein 2; ACT-2; contains: MIP-1-beta(3-69) (CCL4, LAG1, MIP1B, SCYA4)
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Function
- monokine with inflammatory & chemokinetic properties
- binds to CCR5
- one of the major HIV-suppressive factors produced by CD8+ T-cells
- recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV)
- the processed form MIP-1-beta(3-69) retains ability to induce down-regulation of surface expression of the chemokine receptor CCR5 & to inhibit the CCR5-mediated entry of HIV-1 in T-cells
- N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes
- MIP-1-beta(3-69) is also a ligand for CCR1 & CCR2 isoform B
- homodimer & heterodimer of MIP-1-alpha(4-69) & MIP-1-beta(3-69)
Structure
Compartment
Expression
induced by mitogens
Notes
More general terms
Additional terms
References
- ↑ 1.0 1.1 UniProt http://www.uniprot.org/uniprot/P13236.html
- ↑ Wikipedia; Note: macrophage inflammatory protein entry http://en.wikipedia.org/wiki/macrophage_inflammatory_protein
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ Hopkins SJ & Rothwell NJ Cytokines and the nervous system. I: Expression and recognition. TINS 18:83 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7537419
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=388372
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6351
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9560
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:388372
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6351
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9560
- OMIM: https://mirror.omim.org/entry/182284
- UniProt: http://www.uniprot.org/uniprot/P13236.html