C-C motif chemokine 4-like; small-inducible cytokine A4-like; lymphocyte activation gene 1 protein; LAG-1; macrophage inflammatory protein 1-beta; monocyte adherence-induced protein 5-alpha (CCL4L1, CCL4L, LAG1, SCYA4L1, CCL4L2, SCYA4L2)

Function

• chemokine that induces chemotaxis of cells expressing CCR5 or CCR1
• inhibits HIV replication in peripheral blood monocytes that express CCR5
• interacts with CCR5

Structure

belongs to the intercrine beta (chemokine CC) family

Compartment

secreted (putative)

Alternative splicing

named isoforms=10

Expression

detected in B-cells

Polymorphism

• copy number of the CC4L1 gene varies among individuals
• most individuals have 1 to 6 copies in the diploid genome

Notes

• CCL4L1 & CCL4L2 genes differ in their non-coding regions; thus, alternative splicing events differ between the two genes

More general terms

• CC chemokine; beta chemokine

Additional terms

• C-C motif chemokine 4

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3883
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7288
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7304
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9560
• OMIM: https://mirror.omim.org/entry/603782
• UniProt: http://www.uniprot.org/uniprot/Q8NHW4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9560