RANTES; C-C motif chemokine 5; EoCP; eosinophil chemotactic cytokine; SIS-delta; small-inducible cytokine A5; T cell-specific protein P228; TCP228; T cell-specific protein RANTES (CCL5, D17S136E, SCYA5)

Function

• chemoattractant for blood monocytes, memory T-helper cells & eosinophils
• causes release of histamine from basophils & activates eosinophils
• binds to CCR1, CCR3, CCR4 & CCR5
• one of the major HIV-suppressive factors produced by CD8+ T-cells
• recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV)
• the processed form RANTES(3-68) acts as a natural chemotaxis inhibitor & is a more potent inhibitor of HIV-1-infection
• the second processed form RANTES(4-68) exhibits reduced chemotactic & HIV-suppressive activity compared with RANTES(1-68) & RANTES(3-68) & is generated by an unidentified enzyme associated with monocytes & neutrophils
• N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes & cultured sarcoma cells

Structure

• O-linked oligosaccharides at Ser-27 & Ser-28
• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• T-cell & macrophage specific
• induced by mitogens

Polymorphism

• variant Phe-24 is an antagonist of the chemokine receptors CCR1 & CCR3

More general terms

• sis family protein
• CC chemokine; beta chemokine
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6352
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6352
• OMIM: https://mirror.omim.org/entry/187011
• UniProt: http://www.uniprot.org/uniprot/P13501.html