eotaxin; C-C motif chemokine 11; eosinophil chemotactic protein; small-inducible cytokine A11 (CCL11, SCYA11)
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Function
- chemotactic for eosinophils
- promotes accumulation of eosinophils response to allergens
- binds to CCR3
Structure
- O-linked glycan
- consists of a gal-galNAc disaccharide which mofified with up to 2 sialic acid residues
- belongs to the intercrine beta (chemokine CC) family
Compartment
Expression
- induced by TNF, IL1A/interleukin-1 alpha & IFNG/IFN-gamma
- levels increase in blood & CSF with age (in humans)[4]
Laboratory
- CCL11 in CSF may be a marker for chronic traumatic encephalopathy
Comparative biology
- may inhibit learning, memory, & neurogenesis during aging in mice[4]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P51671.html
- ↑ R&D systems' cytokine source book: CCL11 http://www.rndsystems.com/molecule_detail.aspx?m=1367
- ↑ Wikipedia; Note: CCL11 entry http://en.wikipedia.org/wiki/CCL11
- ↑ 4.0 4.1 4.2 Villeda SA et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011 Sep; 477:90 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21886162