Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; neurotactin; small-inducible cytokine D1 (CX3CL1, FKN, NTT, SCYD1, NKAF, A-152E52)

Function

• the soluble form is chemotactic for T-cells & monocytes
• the soluble form is not chemotactic for neutrophils
• the membrane-bound form promotes adhesion of T-cells & monocytes to endothelial cells
• may play a role in regulating leukocyte adhesion & migration processes at the endothelium
• binds to CX3CR1
• soluble short 95 kD form may be released by proteolytic cleavage from the long membrane-anchored form

Structure

• monomer
• O-glycosylated with core 1 glycan or possibly core 8 glycan
• belongs to the intercrine delta family

Compartment

• cell membrane; single-pass type 1 membrane protein
• exists as membrane protein & secreted form

Expression

• expressed in small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney & pancreas
• induced by TNF & IL-1 in pulmonary endothelial cells & umbilical vein endothelial cells

More general terms

• CX3C or CXXXC chemokine
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6376
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6376
• OMIM: https://mirror.omim.org/entry/601880
• UniProt: http://www.uniprot.org/uniprot/P78423.html