P2Y12 purinoceptor; P2Y purinoceptor 12; P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADP receptor P2Y12; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999 (P2RY12, HORK3)

Function

• receptor for ADP & ATP
• coupled to G-proteins that inhibit the adenylyl cyclase second messenger system
• not activated by UDP & UTP
• involved in platelet aggregation

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• highly expressed in platelets
• lower levels in the brain
• lowest levels in the lung, appendix, pituitary & adrenal gland
• expressed in the spinal cord & in fetal brain

Pathology

• defects in P2RY12 are a cause of bleeding disorder

Pharmacology

• target of antiplatelet agents ticagrelor, clopidogrel & prasugrel

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• adenosine diphosphate [ADP] receptor
• glycoprotein

Additional terms

• P2Y12-receptor inhibitor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6480
• OMIM: https://mirror.omim.org/entry/600515
• OMIM: https://mirror.omim.org/entry/609821
• UniProt: http://www.uniprot.org/uniprot/Q9H244.html