P2Y12-receptor inhibitor
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Notes
- prasugrel & ticagrelor more potent antiplatelet agents than clopidogrel & superior in preventing ischemic events, at the cost of increased risk of bleeding[3]
- genetic testing may provide some information on risk of mbleeding[3]
- genotype-guided dual antiplatelet therapy no better than standard clopidogrel-low-dose aspirin after percutaneous coronary intervention[4]
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References
- ↑ Brilakis ES et al. Medical management after coronary stent implantation: A review. JAMA 2013 Jul 10; 310:189 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23839753
- ↑ Bellemain-Appaix A et al Reappraisal of thienopyridine pretreatment in patients with non-ST elevation acute coronary syndrome: a systematic review and meta-analysis. BMJ 2014;349:g6269 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25954988 <Internet> http://www.bmj.com/content/349/bmj.g6269
- ↑ 3.0 3.1 3.2 Susman E. Genetic Testing Aids in Anticoagulant Selection in ACS. Personalized approach tied to clinically meaningful reduction in ischemic and bleeding events. MedPage Today. March 12, 2018 https://www.medpagetoday.com/meetingcoverage/acc/71722
Ardissino D, et al A prospective, randomised, multicentre study of a pharmacogenomic approach to the selection of antiplatelet therapy in acute coronary syndromes. American College of Cardiology (ACC) 2018; Abstract 18-LB-18910-ACC.
Notarangelo FM, Maglietta G, Bevilacqua P, et al Pharmacogenomic approach to selecting antiplatelet therapy in acute coronary syndromes: PHARMCLO trial. J Am Coll Cardiol. March 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29540324 <Internet> http://www.onlinejacc.org/content/early/2018/02/23/j.jacc.2018.02.029 - ↑ 4.0 4.1 Pereira NL et al. Effect of genotype-guided oral P2Y12 inhibitor selection vs conventional clopidogrel therapy on ischemic outcomes after percutaneous coronary intervention: The TAILOR-PC randomized clinical trial. JAMA 2020 Aug 25; 324:761. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32840598 https://jamanetwork.com/journals/jama/fullarticle/2769725