B-cell lymphoma 3-encoded protein; protein Bcl-3 (BCL3, BCL4, D19S37)

Function

• could be a transcriptional activating factor
• functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus
• activated by phosphorylation
• component of a complex consisting of the NF-kappa-B p52- p52 homodimer & BCL3
• component of a complex consisting of the NF-kappa-B p50-p50 homodimer & BCL3.
• interacts with N4BP2 & COPS5

Structure

contains 7 ANK repeats

Compartment

nucleus

Pathology

• chromosomal translocation t(14;19)(q32;q13.1) involving BCL3 with immunoglobulin gene regions may be a cause of B-cell chronic lymphocytic leukemia (B-CLL)

More general terms

• bcl protein (B-cell leukemia/lymphoma protein)

Database

• UniProt: http://www.uniprot.org/uniprot/P20749.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=602
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:602
• OMIM: https://mirror.omim.org/entry/109560