NEDD4-binding protein 2; N4BP2; BCL-3-binding protein (N4BP2, B3BP, KIAA1413)

Function

• has 5'-polynucleotide kinase & nicking endonuclease activity
• may play a role in DNA repair or recombination
• ubiquitinated; this targets the protein for degradation by the proteasome (putative)
• binds NEDD4 (putative)
• binds BCL3 & CREBBP

Structure

• the Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity
• contains 1 CUE domain
• contains 1 Smr domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

More general terms

• Nedd4-binding protein

Additional terms

• B-cell lymphoma 3-encoded protein; protein Bcl-3 (BCL3, BCL4, D19S37)
• E3 ubiquitin-protein ligase NEDD4; cell proliferation-inducing gene 53 protein; neural cell expressed developmentally down-regulated protein 4; NEDD-4 (NEDD4, KIAA0093, NEDD4-1, PIG53)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55728
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55728
• UniProt: http://www.uniprot.org/uniprot/Q86UW6.html