methoxsalen; 8-methoxypsoralen
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Introduction
One of two psoralens available in the US for use in PUVA treatment. Methoxsalen is the most frequently used psoralen with PUVA.
Indications
- symptomatic control of severe, recalcitrant, disabling psoriasis in conjunction with UV-A radiation
- induction of repigmentation in vitiligo (topical agent) in conjunction with UV-A or sunlight
- lichen planus[3]
- alopecia areata
- mycosis fungoides-Sezary syndrome
- cutaneous T-cell lymphoma[3]
Dosage
- psoriasis: (adults) 10-70 mg PO 1.5-2 hours prior to UV-A exposure, 2-3 times, at least 48 hours apart
- vitiligo: (adults & children > 12 years of age)
- oral: 20 mg PO 2-4 hours prior to UV-A or sunlight
- topical: apply lotion 1-2 hours prior to UV-A light not more than weekly
Capsule: 10 mg
Adverse effects
- common (> 10%)
- less common (1-10%)
- severe edema, erythema, hypotension, nervousness, vertigo, depression, rash, pruritus, freckling, painful blistering, burning & peeling of skin, hypopigmentation, cheilitis, loss of muscle coordination