psoralen
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Introduction
Psoralens belong to the furocoumarin class of compounds derived from fusion of furan with a coumarin. They occur naturally in plants including limes, lemons, figs & parsnips.
Uses
4 psoralens are used in PUVA therapy:
- psoralen
- 5-methoxypsoralen (bergapten)
- 8-methoxypsoralen (methoxsalen)
- 4,5,8-trimethylpsoralen (trioxsalen)
Comparative biology
- possible association of psoralen in citrus fruit (orange juice & grapefruit) with increased risk of cutaneous melanoma[2]
- psoralen has photocarcinogenic properties in animals[2]
Notes
- only methoxsalen & trioxsalen are available in the U.S.
- methoxsalen is the primary psoralen used
More general terms
More specific terms
- bergapten; 5-methoxypsoralen
- methoxsalen; 8-methoxypsoralen
- trioxsalen; 4,5,8-trimethylpsoralen (Trisoralen)
Component of
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1609
- ↑ 2.0 2.1 2.2 Wu S, Han J, Feskanich D et al Citrus Consumption and Risk of Cutaneous Malignant Melanoma. JCO published online on June 29, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26124488 <Internet> http://jco.ascopubs.org/content/early/2015/06/24/JCO.2014.57.4111.abstract
Berwick M Dietary Advice for Melanoma: Not Ready for Prime Time. JCO published online on June 29, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26124491 <Internet> http://jco.ascopubs.org/content/early/2015/06/24/JCO.2015.61.8116.full