trioxsalen; 4,5,8-trimethylpsoralen (Trisoralen)

Introduction

One of two psoralens available in the US for use in PUVA treatment.

Indications

• used in conjunction with ultraviolet light or sunlight for repigmentation of idiopathic vitiligo
• photosensitivity
  • increasing tolerance to sunlight in albinism

enhance pigmentation

Dosage

• adults & children > 12 years:
  • 10 mg PO as a single dose 2-4 hours before controlled exposure to UV-A or sunlight

Tabs: 5 mg.

Adverse effects

• common (> 10%)
  • itching, nausea
• less common (1-10%)
  • dizziness, headache, depression, insomnia, nervousness, severe burns from excessive sunlight of ultraviolet exposure, epigastric discomfort

More general terms

• psoralen

Additional terms

• oral psoralen & ultraviolet (UV) A light (PUVA)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5585