cytosine arabinoside; cytarabine (Cytosar, ARA-C, HiDAC, Depocyt)

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Introduction

Tradenames: Cytosar, Depocyt.

Indications

Dosage

  • 60-200 mg/m2 as continuous IV infusion over 5-10 days
  • 10-30 mg/m2 intrathecally 2-3 times weekly
  • 100 mg/m2 IV or SC every 12 hours for 5 days every month
  • doses up to 3 g/m2 IV every 12 hours have been given

Powder for injection: 100 mg, 200 mg, 1g, 2g.

Injection: Liposomal (Depocyt).

Caution:

Pharmacokinetics

  • widely distributed to tissues
  • deactivated by the liver
  • 72% recovered in the urine
  • 1/2life is 2-3 hours (plasma); 2-10 hours (CNS)

elimination via liver

elimination via kidney

1/2life = 2-10 hours

Monitor

Adverse effects

Drug interactions

Test interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 596
  2. 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 533
  5. 5.0 5.1 Deprecated Reference
  6. 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015

Database