deoxycytidine kinase (DCK)

Function

• required for phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) & deoxyadenosine (dA)
• phosphorylates nucleoside analogs widely employed as antiviral & chemotherapeutic agents
• phosphorylated upon DNA damage, probably by ATM or ATR

NTP + deoxycytidine <--> NDP + dCMP

Structure

• homodimer
• belongs to the DCK/DGK family

Compartment

nucleus

More general terms

• kinase or ATP-phosphotransferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1633
• UniProt: http://www.uniprot.org/uniprot/P27707.html
• OMIM: https://mirror.omim.org/entry/125450