cytidine deaminase; cytidine aminohydrolase (CDA, CDD)

Function

• scavenges exogenous and endogenous cytidine & 2'-deoxycytidine for UMP synthesis

cytidine + H2O <--> uridine + NH3

Cofactor: Zn+2

Structure

• homotetramer
• belongs to the cytidine & deoxycytidylate deaminase family

Expression

• highly expressed in granulocytes
• expression is very low in fibroblasts, chondrocytes, monocytes, T-cell & B-cell lines

Genetics

Gene locus: 1p36.2-p35

More general terms

• cytidine deaminase family

More specific terms

• DNA dC->dU-editing enzyme (phorbolin)
• DNA dC->dU-editing enzyme APOBEC-3F (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F, APOBEC3F)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=978
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:978
• OMIM: https://mirror.omim.org/entry/123920
• UniProt: http://www.uniprot.org/uniprot/P32320.html