deoxycytidylate [dCMP] deaminase (DCTD)

Function

• supplies nucleotide substrate for thymidylate synthetase
• allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP & dTTP

dCMP + H2O <--> dUMP + NH3

Cofactor: Zn+2

Structure

• homohexamer
• belongs to the cytidine & deoxycytidylate deaminase family

More general terms

• nucleotide deaminase

Database

• UniProt: http://www.uniprot.org/uniprot/P32321.html
• OMIM: https://mirror.omim.org/entry/607638
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1635