thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)

Function

• pyrimidine metabolism; dTTP biosynthesis

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

Structure

• homodimer
• belongs to the thymidylate synthase family

Laboratory

• TYMS genotyping

More general terms

• oxidoreductase
• methyltransferase
• phosphoprotein

Additional terms

• folate metabolism
• N5,N10-methylenetetrahydrofolate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7298
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7298
• OMIM: https://mirror.omim.org/entry/188350
• UniProt: http://www.uniprot.org/uniprot/P04818.html