N5,N10-methylenetetrahydrofolate

Function

• serine hydroxymethyltransferase catalyzes formation of 5,10-methylenetetrahydrofolate & glycine from serine & tetrahydrofolate
• the methylenetetrahydrofolate is, in turn used by:
  • thymidylate synthase in the biosynthesis of dTMP from dUMP#
  • 5,10 methylenetetrahydrofolate reductase to form N5-methyltetrahydrofolate*

* used by methionine synthase to regenerate methionine from homocysteine

# dihydrofolate results, with reduction by dihydrofolate reductase

More general terms

• tetrahydrofolate (THF)

Additional terms

• 5,10-methylenetetrahydrofolate reductase (MTHFR)
• folate metabolism
• methionine metabolism (trans-sulfuration pathway)
• serine hydroxymethyltransferase (SHMT), serine methylase or glycine hydroxymethyltransferase
• thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=884
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5280324
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=108194
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=136