dihydrofolate reductase (DHFR, tetrahydrofolate dehydrogenase)

Function

• cofactor biosynthesis; tetrahydrofolate biosynthesis
• tetrahydrofolate from 7,8-dihydrofolate
• reaction catalyzed by DHFR represents an essential step for de novo glycine & purine synthesis, DNA precursor synthesis, & for the conversion of dUMP to dTM

5,6,7,8-tetrahydrofolate + NADP+
           <-->
7,8-dihydrofolate + NADPH

Structure

• belongs to the dihydrofolate reductase family
• contains 1 DHFR (dihydrofolate reductase) domain

More general terms

• amine oxidoreductase
• dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P00374.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1719
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6435
• OMIM: https://mirror.omim.org/entry/126060